Angela Griffin was born in Leeds on 19th July 1976. Her bus conductor father Desmond split from his wife Sheila when Angela was four and she and her two brothers were brought up by their mother. She attended Leeds Comprehensive school but also joined the Leeds Children's Theatre and the South Leeds Youth theatre. A talent scout who visited her school got her a job for Yorkshire Television in the series Under the Bedclothes and she also appeared for the same company in Just Us.

In 1992 she guested in Emmerdale and in December of the same year made her Coronation Street debut as hairdresser Fiona Middleton, a part she played until September 1998.

During this period, she won “Best Newcomer” at the 1995 National Television Awards and two years later was one of the stars in the spin-off video Viva Las Vegas!. After the Street, her career has continued to prosper with regular roles in popular series Holby City, Cutting It, Down the Earth and Waterloo Road, and voiced characters on Postman Pat. From 2009 to 2010 she had her own chat show on Sky1 titled Angela and Friends.

She married actor Jason Milligan with whom she has two daughters.