Deborah Brian appeared in three roles in Coronation Street:
- A Nursing Sister based at Victoria Hospital, Blackpool in November 2003
- A Practice Nurse at Rosamund Street Medical Centre who treated Amy Barlow for a suspected milk allergy in May 2011
- A Social Worker who met Tyrone Dobbs at the Cragg Street Children's Contact Centre for a supervised visit to see his daughter Ruby Soames in February 2013.
She is known for her roles in The Spell, The Jumper, and Blue Murder.