Donna Lythgoe has appeared on Coronation Street in three roles:
- Brenda Fox in January and April 1996
- Nurse Dooley in December 2000
- An unnamed Carer in April 2011.
Her other credits include roles in Screen One, Woof!, The Cops, People Like Us, Doctors, Heartbeat, The Innocence Project and Emmerdale, whilst on stage she has appeared in productions including Last Tango in Whitby, Cabaret, Bedroom Farce and Once a Catholic.
She also scripted and performed in the BBC 4 Radio play Four Individual Tarts.