Guy Nicholls appeared on Coronation Street in three roles:
- Harry Redman, the husband of florist Maggie Redman in October and November 1983
- Health and Safety official Mr Ellison in February and June 1990
- Mr Flemming, a governor of Weatherfield Comprehensive in March 1994.
His other credits include roles in Crossroads, How We Used to Live, The Practice, Bulman, All Creatures Great and Small, The Bill, All Quiet on the Preston Front, Peak Practice and the films Wetherby and Little Dorrit, while on stage he has appeared in productions of The Seagull, Murder With Love, Blood Relations, The Misanthrope and Sisterly Feelings.