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Margi first came to attention with a starring role in her first film appearance in 1985's Letter to Brezhnev and later was a regular in TV's Making Out as Queenie.
Other credits include roles in Brookside (credited as "Margi MacGregor", with her brother Frank Clarke penning episodes for the programme during the 1980s), Soul Survivors, Casualty, 24 Hour Party People, Hollyoaks: In the City, Benidorm and Waterloo Road.