Sean Francis appeared on Coronation Street in December 2010 as Will, a chaplain who officiated at Weatherfield General. He conducted an emergency wedding ceremony between Peter Barlow and Leanne Battersby at the critically-ill Peter's bedside; and later in the month he conducted a blessing service for the prematurely-born Hope Stape.

His other television credits include roles in London Bridge, The Knock, Urban Gothic, Night & Day, EastEnders, Holby City, Wire in the Blood, The Bill, Silent Witness, Casualty, Doctors, Being Human and The Enfield Haunting. He also appeared in films including Fierce Creatures, The Tribe, 24 Hours in London and the 2014 remake of RoboCop.